![]() ![]() ![]() These nitogenous products are normally freely filtered through normal glomeruli (but have to reach the glomeruli to be filtered). a decreased glomerular filtration rate (GFR). Renal failure can be a consequence of severe acute kidney injury (AKI) or chronic kidney disease (CKD).Īzotemia indicates that there is a problem with the kidneys filtering nitrogenous waste (urea nitrogen) or products of muscle metabolism (creatinine), i.e. Uremia is the term for the clinical syndrome of renal failure with azotemia and multisystemic problems such as polyuria, polydipsia, vomiting, weight loss, depression, and other sequelae of inadequate renal function (alterations in electrolyte and acid-base balance and water homeostasis). It can result from a variety of disorders including, reduced blood flow to the kidneys with hypovolemia, urinary tract obstruction and renal disease. Azotemia is is a laboratory abnormality and is defined as an increase in urea nitrogen and/or creatinine, due to decreased renal excretion.
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